My genetic risk score is high, but my actual values are normal, shoul I be concerned?

No, in general polygenic risk scores explain only a very small portion of your risk, typically 1 to 10%. Most of your risk stems from your lifestyle and behavior. If your actual values are in the correct range, you have nothing to worry about. It is merely an indication that if you adapt unhealthy behavior, you are more likely it affects your actual blood values or, in case of illness, are more likely to become chronically ill. Our paper on polygenic risk scores is currently under review, but can already be viewed here: